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. Author manuscript; available in PMC: 2011 Aug 12.
Published in final edited form as: J Med Chem. 2010 Aug 12;53(15):5770–5781. doi: 10.1021/jm100582w

Table 2.

Inhibitory Potencies (IC50) of N-(2-Oxo-3-oxetanyl)arylamides (7e-7n,8j,11j) on Rat NAAA Activity.

Cpds. Structure IC50 (nM) ± S.E.M.
7e graphic file with name nihms220270t14.jpg 1,700 ± 400
7f graphic file with name nihms220270t15.jpg 102 ± 21
7i graphic file with name nihms220270t16.jpg 50,000 ± 19,000
7j graphic file with name nihms220270t17.jpg 160 ± 40
8j graphic file with name nihms220270t18.jpg 3,200 ± 800
11j graphic file with name nihms220270t19.jpg >100,000
7k graphic file with name nihms220270t20.jpg 300 ± 20
7l graphic file with name nihms220270t21.jpg 400 ± 20
7m graphic file with name nihms220270t22.jpg 300 ± 100
7n graphic file with name nihms220270t23.jpg 90 ± 10
7g graphic file with name nihms220270t24.jpg 4,400 ± 1,200
7h graphic file with name nihms220270t25.jpg 115 ± 13