. Author manuscript; available in PMC: 2011 Aug 12.

Published in final edited form as: J Med Chem. 2010 Aug 12;53(15):5770–5781. doi: 10.1021/jm100582w

Table 3.

Effects of Compound 7h on Michaelis–Menten Constant (K_m) and Maximal Rate of Reaction (V_max) of Recombinant NAAA expressed in HEK-293 Cells.

Compound 7h (nM)	0	100	200
K_m (μM)	162.2 ± 9.0	128.7 ± 32.8	156.5 ± 23.8
V_max (nmol/min/mg)	17.9 ± 1.6	10.8 ± 2.5^*	6.2 ± 0.2^**

See Experimental Section for details.

^**

P < 0.01;

P < 0.05 vs vehicle