Table 2.
Major goblet cell products
| Study | Name | Other names | Peptide | Functions |
|---|---|---|---|---|
| Lievin-Le Moal and Servin [1], Hollingsworth and Swanson [3], Andrianifahanana et al. [4], Gum et al. [15] | MUC2 | Goblet cell mucin Secretory mucin | Monomer (2.5 MDa) | Major component of mucus layers (protective barrier, lubrication, elimination). Binding sites and nutrient sources of microbes. |
| Oigomer (100 MDa) | ||||
| Hattrup and Gendler [21], Ho et al. [22], Luu et al. [23] | MUC1/MUC3/MUC17 | Membrane-bound mucin | Variable sizes 200– > 2000 kDa | Cell surface protective barrier, extracellular portions cleaved or shed and bioactive for epithelial restitution |
| Taupin and Podolsky [8], Kjellev [52] | TFF3 | Intestinal trefoil factor (ITF) | Monomer (6.6 kDa) | Epithelial restitution and wound healing. Facilitates cell migration. Blocks apoptosis. Increases mucus viscosity and structural integrity of mucus layers. |
| Dimer (13 kDa) | ||||
| Artis et al. [57], Nair et al. [58], Hogan et al. [59], Herbert et al. [60] | RELMβ | Resistin-like molecule β, F1ZZ2 | Monomer (12.5 kDa) | Upregulates MUC2 expression/secretion. Induces goblet cell hyperplasia. Functions as Th2 cytokine-induced immune-effector molecule in resistance to intestinal nematode infection. Inhibits chemotaxis of nematode by direct binding to their chemosensory apparatus. |
| Dimer (25 kDa) | ||||
| Johansson et al. [37], Kobayashi et al. [62] | Fcgbp | Fc-γ binding protein | Full-length protein | Binds 1gG antibodies. Stabilization and cross-linking of the MUC2 mucin networks of the inner firm mucus layer. |
| IgG Fc binding protein | (596 kDa) |