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Extracts from 2D 13C DARR spectra recorded with 20 ms mixing time of Ure2p (black), Ure2p1-93 (blue) and Ure2p70-354 (red) (A and B) indicate that the prion domain is structurally different in its isolated form than in the context of the full-length protein. The globular domain, in contrast, is clearly preserved, as seen in (C and D).
