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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 May 24;20(14):4091–4094. doi: 10.1016/j.bmcl.2010.05.081

Scheme 2.

Scheme 2

Reagents and conditions; a) o-NsCl, 2,6-lutidine, CH2Cl2; b) Rl (R=Me, Et or Pr), K2CO3, MeCN 11; 85% 12; 97% 13; 53%; c) BBr3, CH2Cl2, −78 °C, 75%; d) thioglycolic acid, Et3N, 59%; e) POCl3, Et3N, MeCN, 0 °C to rt; then H2O, pyridine,43%; f) succinic acid, acetone, quant.