Table 2.

Relative reactivation rates of OP inhibited hD134H; hD134H_E202Q and hD134H_F338A.

hAChE	OP	OXIME	Relative Reactivation Rate
wt 1	Paraoxon	2PAM	1
D134H			6
D134H_E202Q			0.1
D134H_F338A			1
wt 2		HI6	1
D134H			3
wt 3	SP CHMPTCh	2PAM	1
D134H			2
wt 4		HI6	1
D134H			0.3
D134H_E202Q			0.02
D134H_F338A			0.002
wt 5	VX analogue	2PAM	1
D134H			1
wt 6	RP IPMPTCh	2PAM	1
D134H			1

The second order rate constants for reactivation of OP inhibited wt hAChE by oximes were:

¹120 M^-1min^-1 (paraoxon inhibited hAChE reactivated by 2PAM)

²45 M^-1min^-1 (paraoxon inhibited wt hAChE reactivated by HI6)

³275 M^-1min^-1 (S_PCHMPTCh inhibited wt hAChE reactivated by 2PAM)

⁴13000 M^-1min^-1(S_PCHMPTCh inhibited wt hAChE reactivated by HI6)

⁵490 M^-1min^-1(VX inhibited wt hAChE reactivated by 2PAM)

⁶270 M^-1min^-1(R_PIPMPTCh inhibited wt hAChE reactivated by 2PAM).

Reactivation of cyclosarin and soman inhibited hAChE was not measured.