Table 5.
Serious adverse events (SAE’s) reported between 2 weeks pre-quit and 6-months post-quit by treatment condition
| Placebo (n = 189) |
Bupropion (n = 262) |
Lozenge (n = 260) |
Patch (n = 264) |
Bupropion + Lozenge (n = 267) |
Patch + Lozenge (n = 262) |
|---|---|---|---|---|---|
| • Hospitalized for chest pain | • Hospitalized after being hit by a car | • Hospitalized for breathing difficulty | • Hospitalized for treatment of a blood clot in leg | • Appendectomy | • Hospitalized for cataract surgery |
| • Hospitalized for cardiac arrhythmia | • Hospitalized for chest pain and transient increase in blood pressure | • Surgery to place stents | • Hospitalized for heart attack | • Hospitalized due to breast infection | • Inpatient tonsillectomy |
| • Hospitalized for bronchitis | • Medication blind was broken at request of MD; no other info available | • Vein transplant surgery related to dialysis | • Hospitalized because of auto accident | • Hospitalized due to falling | • Inpatient hysterectomy because of ovarian tumor |
| • Hospitalized for pneumonia | • Hospitalized for abdominal pain | • Hospitalized for CAD and TIA | • Hospitalized for mild heart attack | • Inpatient carpal tunnel surgery | • Hospitalized for pneumonia |
| • Hospitalized for respiratory infection | • Inpatient treatment for alcohol dependence | • Death due to COPD and coronary artery disease | • Hospitalized for stress-related chest pain | ||
| • Hospitalized for pneumonia | • Hospitalized for seizures* | • Hospitalized for lung infection | |||
| • Hospitalized for shortness of breath and heart problems |
*
The only SAE labeled as possibly related to study medication. Seizures are an identified potential side effect of bupropion, which the participant was taking at the time of the seizure.