FIG. 4.

T-cell epitope mapping of CON6, CON-S, and subtype Env immunogens. All of the epitopes identified in both MHC haplotypes are shown in (A). A schematic representation of the HIV-1 envelope relative structural elements is represented in (B). The approximate location of the epitopes induced by the envelope immunogens in BALB/c and C57BL/6 mice are shown in (C) and (D), respectively. Lines represent the epitope positions relative to the signal peptide, variable regions, gp120, gp41, and heptad repeats. Boxed epitopes are MHC class 1 restricted CTL epitopes, and bolded epitopes are common in both MHC haplotypes. BALB/c epitopes are labeled B1–B13, and C57BL/6 epitopes are labeled C1–C10.