Table 1.

Clinical Characteristics of Study Subjects and Tissue Sample Viral Loads

				Viral load (HIV copy #/105cells)b
Patient	Last CD4 count (cells/μl)	Clinical dementiaa	HIV encephalitisa	Brainc	Lymphoidd
MACS1e	2	Yes	Severe	194	254 (SP)
MACS2e	52	Yes	Moderate	156	1080 (LN) 300 (SP)
MACS3e	95	Yes	Moderate	80	12600 (LN)
UK6	54	Yes	Severe	82	291 (SP)

^aDetermined by clinical history prior to and neuropathological examination at autopsy.

^bReal time PCR quantitation of HIV genomes/(Real time PCR quantitation of CCR5 copies/2 copies of CCR5 per cell × 10⁵ cells).

^cBrain samples were collected from the frontal lobe.

^dLymphoid tissue samples were collected from spleen (SP) and/or lymph node (LN).

^eClinical history and neuropathology were previously described in Gorry et al.⁸ and Agopian et al.^5,11