Table 1.
Epithelial-mesenchymal interactions in the mammary gland
| Signaling by stroma |
Signaling by epithelium |
|||
|---|---|---|---|---|
| Stromal ligand/cue | Epithelial receptor | Epithelial ligand/cue | Stromal receptor | |
| During ductal development/puberty | HGF | cMet | Amphiregulin | EGFR (ErbB1) |
| IGF-I | IGF-I receptor | TGF-β | TGFβR-I, -II | |
| Activin/inhibin B | Activin receptors | PTHrP | PTHrP receptor | |
| Epimorphin | Unknown | |||
| MMP-2, -3, -9, -11 | N/a | |||
| During alveolar development/pregnancy | Neuregulin | ErbB3/ErbB4 | ||
| Activin/inhibin B | Activin receptors | |||
| KGF (FGF-7) | FGFR2-IIIb | |||
| Epimorphin | Unknown | |||
| MMP-3 | N/a | |||