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β1 integrin and EGFR protein levels and signal activation are coordinately modulated in HMT-3522 cells cultured in 3D lrBM but not in 2D. When 3D T4–2 cells are treated with functional inhibitors of either β1 integrin or EGFR (T4–2 treated) to revert the cells, endogenous β1 and EGFR protein levels down-modulate coordinately. This phenomenon does not occur in 2D. (Reproduced with permission of Cancer Research from Bissell et al, 1999.)
