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. Author manuscript; available in PMC: 2010 Sep 3.
Published in final edited form as: Differentiation. 2002 Dec;70(9-10):537–546. doi: 10.1046/j.1432-0436.2002.700907.x

Fig. 8.

Fig. 8

Polarized mammary structures are resistant to apoptosis induction. S1 acini within 3D lrBM were treated with E-cadherin blocking antibody to perturb polarity. T4–2 structures within 3D lrBM were treated with beta-1 integrin inhibitory antibody to restore polarity. A Confocal microscopy of beta-catenin and laminin-5. S1 and reverted T4–2 acini have junctionally organized beta-catenin and basally secreted laminin-5, in contrast to disrupted S1 and disorganized T4–2 colonies. B Apoptotic index of the cell cultures in (A), either untreated (basal), or treated with etoposide, Fas-R, or TNF-α. (Reproduced with modification by permission Cancer Cell from Weaver et al, 2002.)