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Components of E-cadherin-mediated adherens junctions. E-cadherin is a cell surface molecule composed of five repeating motifs that contain calcium-binding domains. In the presence of extracellular calcium, E-cadherin molecules homodimerize and then associate with E-cadherin dimers on adjacent cells in a zipper-like mechanism. This process is coincident with association with actin filaments through cytoplasmic adapters including the catenins and α-actinin.
