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. 2010 Sep 3;5(9):e12584. doi: 10.1371/journal.pone.0012584

Figure 2. PPARA −54,642 A variant is less responsive to ERR-mediated co-activation.

Figure 2

Mean normalized luciferase activities (±SE) in (A) C2C12 myobalst cells or (B) CV1 cells cotransfected with PPARA −54,642 A or PPARA −54,642 G promoter-reporter constructs +/− a mammalian expression vector that overexpresses ERRα as indicated. Asterisks represent significantly different transcriptional activation compared to vector control (p<0.05). Four independent trials were performed in triplicate for each cell line.