TABLE 1.

IMMUNOSUPPRESSIVE REGIMENS USED IN PIG-TO-BABOON LIVER TRANSPLANTATION

Baboon #	Donor Pig #	Pig Type	Immunosuppressive Therapy	Survival (days)
B3108	P8208	GTKO	ATG + TAC + MMF + CS	6
B3208	P14508	GTKO/CD46	ATG + TAC + MMF + CS	4
B7708	P21708	GTKO/CD46	ATG + TAC + MMF + CS	7
B7808	P22108	GTKO/CD46	ATG + TAC + MMF + CS	6
B18508	P3909	GTKO/CD46	ATG + TAC + MMF + CS + CVF	5
B18908	P4009	GTKO/CD46	CyP + TAC + MMF + CS	6

ATG = thymoglobulin (5-10 mg/kg i.v. on days -3 and -1 according to T cell count); TAC = tacrolimus (0.05-0.1 mg/kg x2 daily i.m. to maintain 12h blood trough levels of 10-15 ng/mL); MMF = mycophenolate mofetil (110 mg/kg/day by continuous i.v. infusion to maintain blood levels of 3-5 μg/mL); CS = corticosteroids (10 mg/kg i.v., tapering from day of transplant); CVF = cobra venom factor (1-3 mg i.v. on days -1 to 1); CyP = cyclophosphamide (40 mg/kg and 20 mg/kg on days -2 and -1, respectively).