TABLE 2.
COAGULATION FACTORS OF HEALTHY BABOONS AND GENETICALLY-ENGINEERED PIGS, AND COMPARISON WITH VALUES FOR HUMANS, PIGS, AND BABOONS REPORTED IN THE LITERATURE
| W | F I | F II | F V | F VII | F VIII | F IX | F X | F XI | F XII | Pmgn | Pr C | Pr S | AT | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HUMANS (RANGE) |
(kg) | 150-350 mg/dl |
0.7-1.3 U/mL |
0.7-1.5 U/mL |
0.6-1.6 U/mL |
0.6-1.5 U/mL |
0.6-1.5 U/mL |
0.7-1.5 U/mL |
0.6-1.4 U/mL |
0.5-1.7 U/mL |
75-150 % |
70-140 % |
58- 128 % |
80-120 % |
| BABOONS | ||||||||||||||
| B7708 | 9.4 | 210 | 1.54 | 1.82 | 2.13 | 1.09 | 0.61 | 1.12 | 0.72 | 1.91 | 4.3 | 147.9 | 34.4 | 127 |
| B7808 | 10.1 | 201 | 1.32 | 1.66 | 1.62 | 1.21 | 0.56 | 0.88 | 0.71 | 2.78 | <0.1 | 111 | 37.7 | 108 |
| B18208 | 8.3 | 170 | 1.43 | 1 | 2.19 | 0.87 | 0.66 | 0.86 | 0.88 | 2.33 | <0.1 | 133.2 | 34.8 | 111 |
| B18408 | 8.8 | 157 | 1.31 | 0.75 | 1.65 | 1.06 | 0.7 | 0.85 | 0.83 | 2.3 | <0.1 | 110.9 | 44.7 | 115 |
| B18508 | 11.5 | 148 | 1.39 | 1.29 | 1.46 | 0.7 | 0.6 | 0.81 | 0.86 | 1.99 | <0.1 | 136.6 | 45.7 | 90 |
| B18608 | 8.9 | 350 | 1.38 | 1.04 | 2.84 | 0.87 | 0.64 | 0.81 | 1.01 | 1.63 | <0.1 | 124 | 27.5 | 91 |
| B18908 | 10 | 126 | 1.09 | 0.84 | 2.06 | 0.58 | 0.55 | 0.81 | 0.83 | 1.85 | <0.1 | 107.8 | 41 | 88 |
| mean±SD (n=7) | 9.6±1.1 | 195±75 | 1.35±0.14 | 1.20±0.41 | 1.99±0.47 | 0.91±0.22 | 0.62±0.05 | 0.88±0.11 | 0.83±0.10 | 2.11±0.38 | 0.7±1.6 | 124±15 | 38±6 | 104±15 |
| BABOONS [Ezzelarab et al, ref#18] | ||||||||||||||
| mean±SD (n=5) | 149±26 | 1.14±0.22 | 146±22 | 32±8 | 101±19 | |||||||||
| GENETICALLY-ENGINEERED PIGS (GTKO and GTKO/CD46) | ||||||||||||||
| P2109 | 11.5 | 352 | 0.94 | >6.02 | 1.27 | 6.02 | 3.8 | 1.45 | 3.01 | 1.57 | <0.1 | <10 | <10 | 80 |
| P3909 | 6 | 333 | 1.01 | >6.02 | 1.47 | >6.12 | 4.53 | 1.49 | 4.51 | 1.41 | <0.1 | <10 | <10 | 87 |
| P4009 | 5.8 | 330 | 1.28 | >6.02 | 1.44 | >6.12 | 3.55 | 1.26 | 3.42 | 1.2 | <0.1 | <10 | <10 | 76 |
| P14408 | 6.5 | 363 | 1.66 | >6.02 | 2.14 | >6.12 | 3.78 | 1.51 | 3.74 | 3 | 1.6 | <10 | <10 | 60 |
| P14508 | 6.7 | 535 | 1.8 | >6.02 | 2.17 | >6.12 | 3.55 | 1.26 | 3.38 | 2.95 | <0.1 | <10 | <10 | 73 |
| P21708 | 3.4 | 305 | 0.56 | >6.02 | 6.08 | 5.96 | 6.05 | 4.82 | 5.95 | 2.89 | 10 | <10 | <10 | 66 |
| P22108 | 6.7 | 493 | 0.61 | >6.02 | 1.93 | 5.96 | 3.97 | 2.01 | 4.49 | 1.33 | 8 | 20 | 20 | 55 |
| mean±SD (n=7) | 6.7±2.4 | 387±89 | 1.12±0.48 | 6.02±0.0 | 2.36±1.68 | 6.06±0.08 | 4.18±0.89 | 1.97±1.28 | 4.07±1.00 | 2.05±0.85 | 2.9±4.3 | 11±4 | 11±4 | 71±11 |
| WILD-TYPE PIGS [Lewis et al, ref#37] | ||||||||||||||
| mean (n=14) | 309 | 0.64 | 4.73 | 2.09 | 6.13 | 4.18 | 1.89 | 1.43 | 4.95 | 8 | 71 | 8 | 111 | |
| standard pig (n=6) | 60-180 | 348 ± 78 | 0.68 ± 0.3 | 2.80 ± 0.6 | 1.92 ± 0.4 | 6.42 ± 0.8 | 3.20 ± 0.3 | 2.54 ± 0.9 | 1.67 ± 0.3 | 5.65 ± 1.4 | 50 ± 10 | 70 ± 10 | 10 ± 0 | 109 ± 20 |
| mini pig (n=4) | 30-50 | 251 ± 104 | 0.43 ± 0.1 | 5.15 ± 0.8 | 1.67 ± 0.8 | 5.88 ± 1.0 | 4.10 ± 1.4 | 1.06 ± 0.3 | 1.16 ± 0.5 | 3.98 ± 0.7 | 8 ± 2 | 56 ± 20 | 7 ± 1 | 111 ± 5 |
| micro pig (n=4) | 20-40 | 310 ± 67 | 0.80 ± 0.6 | 7.20 ± 3.3 | 2.75 ± 1.7 | 5.95 ± 1.0 | 5.73 ± 1.5 | 1.75 ± 0.9 | 1.35 ± 0.1 | 4.95 ± 1.2 | 10 ± 1 | 94 ± 12 | 7 ± 1 | 118 ± 1 |
Pmgn = plasminogen; PrC = protein C; PrS = protein S; AT = antithrombin; SD = standard deviation; W = weigh.
Where a value is expressed as < or >, these values have been used to calculate mean and SD values.