Fig. 1.
BoNT/C treatment of striatal tissue increases DA transport activity. Rat striatal slices were treated with 100 ng/ml BoNT/C for the indicated times (A, C) or for 1h with the indicated doses (B, D) followed by [3H]DA uptake assay or western blotting for DAT or syn 1A. A. and B., [3H]DA uptake activity (means ± S.E. of 3 independent experiments performed in triplicate). *, p<0.05; **, p<0.01 relative to control by ANOVA. C. and D., representative DAT and syn 1A immunoblots from treated tissue. Molecular mass markers are shown in kDa.