Table 4.

Base Pairs and DNMs Surveyed among ASD and SCZ Trios with No Family History

Site and Mutation Class		Initial Counta	CpGb	Non-CpG	Effective Countc
Functional	Nonsynonymous bases	96,065,492	2,689,834	93,375,658	120,273,996
	Nonsynonymous DNMs	6	3	3	6
Neutral	Synonymous bases	61,481,915	1,721,494	59,760,421	76,975,357
	Intronic bases	218,145,769	2,181,458	215,964,311	237,778,888
	Silent (synonymous and intronic) DNMs	4	2	2	4
p value	One-tail binomial testd	0.003	0.161	0.031	0.008
	Fisher's exact test	0.022	0.4041	0.1067	0.032

^aAll statistics are calculated with base pairs and DNMs calculated for only trios with unaffected families.

^bEstimated 2.8% of initial coding sites and 1% of initial intronic sites are CpG sites.

^cTo account for increased mutation rates: (non-CpG sites) + (10 × CpG sites).

^dP(× ≥ number of functional DNMs | nonfunctional rate).