High, Medium, Low Oxidative Stress refer to as the first, second and third tertile of log F2-isoprostane concentrations. The Figure shows the predicted risk in increasing calcification from the proportional odds model including interaction between log F2-isoprostanes and HDL adjusted for age, sex, race, hypertension, smoking, BMI, diabetes and statin use. Predicted probabilities of HDL on coronary calcium by each level of oxidative stress (high, medium, low) were obtained by using the median values of each tertile of log-F2-isoprostanes. (P value for interaction=0.07). The interaction is significant when adjusted for age, race and sex (p=0.02).