Table 1.
Clinical Factors and Urinary F2-Isoprostane Excretion in Patients with RA and Control Subjects
| Factor | Controls (N=92) | RA (N=169) | P value |
|---|---|---|---|
| Age (Years) | 53.0 [44.8-59.2] | 54.0 [45.0-63.0] | 0.41 |
| Sex (Male%) | 37.0% | 30.8% | 0.31 |
| Race(Caucasian%) | 84.8% | 88.2% | 0.44 |
| BMI (kg/m2) | 27.0 [24.6-31.8] | 28.3 [24.0-33.2] | 0.44 |
| Current Smokers | 8.7% | 24.3% | 0.002 |
| Hypertension | 39.1% | 53.3% | 0.03 |
| Diabetes | 4.3% | 11.2% | 0.06 |
| Statin Use | 13.0% | 12.4% | 0.89 |
| Disease duration (years) | - | 3 [2-18] | - |
| Current Corticosteroid Use | - | 54.4% | - |
| Current Methotrexate Use | - | 71.0% | - |
| Current Antimalarial Use | - | 24.9% | - |
| Current anti-TNF agent use | - | 20.7% | - |
| HDL cholesterol (mg/dl) | 45.0 [38.5-54.0] | 43.0 [37.0-54.0] | 0.65 |
| LDL cholesterol (mg/dl) | 122.0 [104.0-145.0] | 112.5 [88.8-135.2] | 0.02 |
| Triglycerides (mg/dl) | 103.0 [73.0-135.5] | 110.5 [79.8-158.0] | 0.22 |
| Glucose(mg/dl) | 89.0 [83.0-94.2] | 87.0 [83.0-94.0] | 0.70 |
| HOMA Index | 0.83 [0.54-1.79] | 2.36 [1.19-4.47] | <0.001 |
| Framingham Score | 12.0 [7.0-14.0] | 13.0 [9.0-16.0] | 0.10 |
| Coronary Calcification Score | 0.0 [0.0-18.7] | 1.9 [0.0-150.3] | 0.02 |
| DAS28 Score | - | 3.88 [2.64-4.84] | - |
| F2-isoprostanes (ng/mg Cr) | 1.86 [1.25-2.62] | 2.75 [1.60-4.06] | <0.001 |
Data are expressed as median [interquartile range] or percentage(%).