Table 1.

Analysis of SNPs in the CARD9/SNAPC4 region. Significant associations are highlighted in bold. Positions are taken from Ensembl Genome Browser (www.ensembl.org) (August 2009). NS non-synonymous with amino acid change in brackets, S synonymous, US upstream, DS downstream, UTR untranslated region.

¹OR >1.0 because the minor allele (A) in the controls was designated the minor allele although it is the major allele in the cases.

58BC are 1500 controls genotyped by WTCCC

OxC are 1020 local controls described in materials and methods

2Dis controls and 3Dis controls are genotypes from the diseases other than AS genotyped by WTCCC

WTCCC study is the nsSNP study of 1000 AS cases and 1500 58BC controls.