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. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Cancer Res. 2010 Jul 27;70(17):6902–6912. doi: 10.1158/0008-5472.CAN-10-1440

MT-MMPs are elevated in human preclinical tumor models. Expression of MMP mRNA in human cell lines grown in vitro (A) and as xenografts in vivo (B) as measured by quantitative RT-PCR. Expression values after normalization to 18S-rRNA and are gene specific. Classification of expression levels was determined from the C_T of each gene as either very high (C_T ≤ 25), high (C_T = 26-30), moderate (C_T = 31-35), low (C_T = 36-39), or not detected (CT = 40); see key for color scheme. (C) Immunoblot of MT1-MMP protein expression in HT1080 and MCF7 tumor models.

Key for qRT-PCR expression:

graphic file with name ukmss-31558-f0002.jpg — MT-MMPs are elevated in human preclinical tumor models. Expression of MMP mRNA in human cell lines grown in vitro (A) and as xenografts in vivo (B) as measured by quantitative RT-PCR. Expression values after normalization to 18S-rRNA and are gene specific. Classification of expression levels was determined from the C_T of each gene as either very high (C_T ≤ 25), high (C_T = 26-30), moderate (C_T = 31-35), low (C_T = 36-39), or not detected (CT = 40); see key for color scheme. (C) Immunoblot of MT1-MMP protein expression in HT1080 and MCF7 tumor models.

Key for qRT-PCR expression: