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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Cancer Res. 2010 Jul 27;70(17):6902–6912. doi: 10.1158/0008-5472.CAN-10-1440

Figure 4.

Figure 4

Induction of tumor vascular disruption and hemorrhagic necrosis by ICT2588 in vivo. Mice bearing HT1080 tumors were treated with ICT2588 or ICT2552 and assessed for functional vasculature (A) and hemorrhagic necrosis (B) 24 h post-treatment. Graph represents mean values from 3 mice ± standard error. Image (A) demonstrates loss of functional tumor vasculature, (as described previously, see refs. 37, 40, 41) are indicated in (A). Image (B) demonstrates the persistence of a viable tumor rim.