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Differential chemosensitivity of the peptide-conjugate (ICT2588) and active metabolite (ICT2552) against MT1-MMP positive (HT1080) and negative (MCF7) cell lines in vitro. Values are reported as IC50. Values represent the mean for 3 independent experiments ± standard deviation. Shaded areas indicate a positive cytotoxic response.
| Compound | HT1080 IC50 (nM) |
MCF7 IC50 (nM) |
|
|---|---|---|---|
| 24 hour | ICT2588 | 522 ±76 | < 5000 |
| ICT2552 | 36 ±5 | 64 ±28 | |
| 96 hour | ICT2588 | 176 ±39 | < 5000 |
| ICT2552 | 31 ±1.3 | 63 ±20 |
