Skip to main content
. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Cancer Res. 2010 Jul 27;70(17):6902–6912. doi: 10.1158/0008-5472.CAN-10-1440

Table 1.

Differential chemosensitivity of the peptide-conjugate (ICT2588) and active metabolite (ICT2552) against MT1-MMP positive (HT1080) and negative (MCF7) cell lines in vitro. Values are reported as IC50. Values represent the mean for 3 independent experiments ± standard deviation. Shaded areas indicate a positive cytotoxic response.

Compound HT1080
IC50 (nM)
MCF7
IC50 (nM)
24 hour ICT2588 522 ±76 < 5000
ICT2552 36 ±5 64 ±28
96 hour ICT2588 176 ±39 < 5000
ICT2552 31 ±1.3 63 ±20