Figure 1.

Endogenous production of lipid mediator using omega-6 fatty acid, i.e., arachidonic acid, which is cleaved by phospholipase A2 (PLA2) and becomes the substrate for cyclooxygenases (Cox-1 and -2) and Lipooxygenases (5-LO, 12-LO, and 15-LO) to form potent proinflammatory mediators. Later, with specific transcellular and cell:cell-specific interactions, they form lipoxins, which help in resolution. Thus, active production of endogenous lipid meditors help in the resolution of inflammation