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Body weight changes of mice post-challenge. Mice unexposed or pre-exposed to H1N1 virus were immunized with a single dose of H5N1 virus NP (A), M1 (B) or NP + M1 DNAs (C), respectively. Six weeks after immunization, all the mice were challenged with a lethal dose (20LD50) of H5N1 virus. Body weights of mice were recorded at 0, 3, 7, 10, 14, and 21 days after challenge.
