Table 1.

Amino acid sequences and genetic characteristics of antibody light-chain and heavy-chain genes amplified from MS donors 95-2 and 99-1

Antibody library tissue source	Clone designation	HCDR3	LCDR3	Frequency of representation in the library	Family	Germ line	Homology to germ line, %
Acute brain plaque/periplaque (donor 95-2)	A	GDKTSTDY		11/26	VH4	DP63	90.0
		HPHLLDLSWFDP		2/26
		TRYSSGFHSFYY		2/26
CSF (donor 99-1)	B	DGATGSGYWFDH		16/16	VH1	DP8	98.2
Acute brain plaque/periplaque (donor 95-2)	A		QGYGNLFT	3/16	VK1	DPK1	96.0
CSF (donor 99-1)	B		QQYHSYPWT	12/17	VK1	HK102	91.9
			QQSFSTPYT	3/17

Boldface indicates predominant HCDR3 and LCDR3.