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. 2010 Aug 21;5:66. doi: 10.1186/1749-8090-5-66

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Copyright ©2010 Weissen-Plenz et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlation between inflammatory infiltration and collagen degradation. Picro Siriusred staining (panel A: collagen deposition = red) showing areas with massive collagen degradation. Immunohistochemistry for CD68 (panel B) and 27E10 (panel C) demonstrated accumulation of infiltrating cells particularly at the intima-media border (arrows indicate areas with profound vascularization). MMP1 (panel D) and MMP9 (panel E) were strongly expressed at the intima-media border and in deeper areas of the media. Interestingly, MMP2 expression was only very low (not shown). In situ zymography (panel F: collagenolysis) showed massive collagenolytic activity at the intima-media border and in deeper areas of the media. (m: media; i: intima; original magnification: ×100)