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Oxygen consumption, Respiratory Quotient, and unbound plasma exposure in S-D rats administered CE-178253
| Dose (mg/kg, p.o.) | VO2, ave, 1-3 hr ( ± S-D) |
Respiratory Quotient (VCO2/VO2) |
Unbound Plasma Concentration (nM ± S-D ) |
Unbound plasma/rat brain CB1 R Ki |
|---|---|---|---|---|
| Veh. | 3 ± 5 | 0.85 ± 0.03 | NA | NA |
| 1 | 28 ± 7* | 0.74 ± 0.02* | 0.8 ± 0.2 | 1.8 |
| 3 | 39 ± 5* | 0.75 ± 0.03* | 3.8 ± 0.9 | 8.8 |
*significantly different from veh. p < 0.05
