Table 3.

Association of anthropometric and radiographic-based measures of adipose tissue with MRI-markers of vascular brain injury

		White matter hyperintensity volume (N=733)		Extensive white matter hyperintensity volume (N=733)		Brain infarcts (N=733)
		Estimate* ± SE	p	OR [95%CI]	p	OR [95%CI]	p
Body mass index
per SD	model A	−0.02±0.03	0.595	0.92 [0.77–1.10]	0.352	0.88 [0.71–1.10]	0.274
	model B	−0.04±0.04	0.239	0.83 [0.69–1.00]	0.048	0.83 [0.66–1.06]	0.136
Waist circumference
per SD	model A	−0.03±0.04	0.352	0.96 [0.81–1.14]	0.635	0.82 [0.65–1.02]	0.075
	model B	−0.06±0.04	0.133	0.87 [0.72–1.05]	0.140	0.77 [0.61–0.98]	0.033
Waist to hip ratio
per SD	model A	−0.03±0.04	0.453	1.06 [0.88–1.27]	0.536	0.84 [0.67–1.05]	0.120
	model B	−0.05±0.04	0.190	0.98 [0.81–1.19]	0.857	0.80 [0.63–1.01]	0.063
Subcutaneous adipose tissue
per SD	model A	−0.05±0.04	0.176	0.89 [0.75–1.06]	0.191	0.88 [0.70–1.10]	0.262
	model B	−0.06±0.04	0.077	0.83 [0.69–1.00]	0.052	0.85 [0.67–1.07]	0.166
Visceral adipose tissue
per SD	model A	−0.02±0.04	0.518	0.90 [0.75–1.08]	0.249	0.81 [0.65–1.02]	0.068
	model B	−0.05±0.04	0.225	0.82 [0.68–1.00]	0.045	0.78 [0.62–0.98]	0.033
	model C	−0.02±0.05	0.741	0.92 [0.72–1.17]	0.501	0.80 [0.60–1.08]	0.149
	model D	−0.02±0.05	0.620	0.89 [0.70–1.15]	0.372	0.80 [0.59–1.08]	0.149

SD: standard deviation; SE: standard error; model A: linear regression (for white matter hyperintensity volume) or logistic regression (for extensive white matter hyperintensity volume and brain infarcts) adjusted for age, sex and time between CT and MRI; model B: model A additionally adjusted for systolic blood pressure, smoking, diabetes mellitus and history of cardiovascular disease and physical activity index; model C: model A additionally adjusted for BMI; model D: model B additionally adjusted for BMI;

^*Estimates are regression coefficients for white matter hyperintensity volume, per SD of increasing adiposity measures.