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Estrogen-independent evolution of tumors induced by RCAS-PyMT. (A and B) MMTV-tva mice at the age of 6 (A) or 12 (B) weeks were infected with RCAS-PyMT (104 IU/gland, one set of nos. 2–4 glands per mouse). One week later, the infected mice were randomized and treated with ovariectomy or sham surgery. Tumor appearance was monitored by daily palpation.
