. Author manuscript; available in PMC: 2010 Sep 6.

Published in final edited form as: Biochemistry. 2008 Sep 5;47(39):10420–10427. doi: 10.1021/bi800904m

Table 6.

Summary of product inhibition results for AcH4-21

Inhibitor	Varied Substrate	Fixed Substrate	Inhibition Pattern	K_is (µM)	K_ii (µM)	Equation
AcH4-21R₃ADMA	AcH4-21	SAM^a	Competitive	39.7 ± 12.4		(3)
AcH4-21R₃ADMA	SAM	AcH4-21^b	Noncompetitive/ Mixed	23.1 ± 6.8	102 ± 36	(5)
AcH4-21R₃ADMA	SAM	AcH4-21^c	No Inhibition
SAH	AcH4-21	SAM^a	Noncompetitive	19.7 ± 2.1	19.7 ± 2.1	(4)
SAH	SAM	AcH4-21^b	Competitive	0.11 ± 0.03		(3)
SAH	SAM	AcH4-21^c	Competitive	6.5 ± 1.6		(3)

[SAM] = 15 µM

[Peptide] = 10 µM

[Peptide] = 500 µM