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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: J Neurochem. 2010 Jan 8;112(6):1584–1592. doi: 10.1111/j.1471-4159.2010.06573.x

Figure 2.

Figure 2

Temporal requirement of the RPE-derived VEGF in choroidal vascular development. A–K: representative images of anti-CD31 antibody-stained large choroidal vessels and capillaries from P21 conditional VEGF KO mice and WT mice after dox induction at E10-12, E13-15, E16-18, or P4–P6. C: black-white image converted from B, which was used to calculate the area of vessels. M: quantification of choroidal vascular density. *: p<0.05 vs WT in t-test. ns: not significant. Inducible disruption of the RPE-derived VEGF at various times resulted in regulatable changes in choroidal vascular density and the RPE-derived VEGF was required for the development of choroidal vasculature before embryonic day 15.