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. Author manuscript; available in PMC: 2010 Sep 6.
Published in final edited form as: Annu Rev Biochem. 2008;77:313–338. doi: 10.1146/annurev.biochem.77.061306.123941

Figure 6.

Figure 6

DNA ligase IV family. Alignment of the DNA ligases encoded by the S. cerevisiae DNL4 and human LIG4 genes. The DNA-binding domain (DBD, red) and the catalytic core composed of the adenylation and OB-fold domains (gray) are indicated. The position of the active-site lysine residues (K282, K213) within the adenylation domain that form the covalent bond with AMP are shown. The positions of the tandem BRCT domains (green) in the C-terminal regions of yeast Dnl4 and human DNA ligase IV (human LigIV) and a phosphorylated serine (Ser650) residue in human DNA ligase IV are shown (89). Abbreviation: aa, amino acids.