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. Author manuscript; available in PMC: 2010 Sep 6.
Published in final edited form as: Chem Res Toxicol. 2010 Feb 15;23(2):413–421. doi: 10.1021/tx900372p

Figure 3. Induction of DNA crosslinking by photoactivated Pt complexes.

Figure 3

DNA migration was induced by incubating irradiated cells with H2O2 before cells were processed in the comet assay. Migration of coded samples was assessed by image analysis (Komet v. 5.5) and the degree of crosslinking calculated. A: Irradiated samples; B: Sham irradiated samples (5 J cm−2 UVA). Data points represent the mean of 4/6 monolayers from 2/3 independent experiments. Background DNA migration: +UVA: 9.9 ± 1.5%; Sham: 8.8 ± 1.1%.