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. Author manuscript; available in PMC: 2010 Sep 6.
Published in final edited form as: Chem Res Toxicol. 2010 Feb 15;23(2):413–421. doi: 10.1021/tx900372p

Table 4.

Fold difference in toxicity of photoactivated Pt complexes compared to cisplatin tested under identical conditions (i.e. values > 1 indicate greater potency for photoactivated complexes)

Complex IC50 (cisplatin)/IC50(photoPt)
HaCaT A2780 A2780CIS
1c[a] 0.9 1.1 1.3
1t[a] 1.2 1.5 1.6
2t 2.2 3.8 2.0
8c 1.1 2.3 1.6
8t 2.7 3.0 4.4
9c 0.6 2.4 1.1
9t[c] 6.5 58.2 90.0
7c 1.4 1.9 2.4
7t[a] 21.2 80.0 15.4
3t 2.1 2.6 2.9
4c 0.7 1.6 ND[b]
5c 1.0 ND[b] ND[b]
6c 0.6 0.6 1.1
[a]

Previously reported in (19) (1t,c) and (11) (7t)

[b]

ND = not determined

[c]

Cytotoxic.