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. Author manuscript; available in PMC: 2010 Sep 6.
Published in final edited form as: Drug Discov Today. 2009 Sep 24;14(23-24):1089–1097. doi: 10.1016/j.drudis.2009.09.003

FIGURE 2.

FIGURE 2

Examples of metal-based compounds that target DNA. (a) X-ray structure showing the kinking of DNA by cisplatin (pdb1aio) (b) NAMI-A. (c) KP1019. (d) General structure of organometallic ruthenium(II) and osmium(II) arene complexes. (e, f) Examples of cytotoxic RuII arene complexes. (g) model showing intercalation of a RuII arene complex into DNA. (h) [γ-Ru(azpy)2Cl2]. (i, j) Examples of cytotoxic OsII arene complexes.