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Mechanism of LPS-induced decreased expression of PS and C4BP in hepatocytes. LPS binds to membrane-bound CD14 and TLR-4, followed by activation of MEK/ERK and NFκB. Activated NFκB interacts with the promoter regions of the PS and C4BPα and C4BPβ genes, leading to decreased PS expression in hepatocytes and SECs, and decreased C4BP expression in hepatocytes.
