Figure 2.

Processes controlled by the ZEB/miR-200 feedback loop. (A) ZEB factors are induced by the indicated factors resulting in activation of the listed processes. Owing to the feedback loop, miR-200 members induce opposite processes. Little is known about factors that activate the expression of miR-200 family members. (B) An example showing that ZEB and miR-200 not only block expression of each other, but also ZEB1 suppresses transcription of miR-203 and miR-183, which together with miR-200 inhibit expression of stem-cell factors, linking the induction of EMT and the maintenance of stemness (Wellner et al, 2009). EMT, epithelial-to-mesenchymal transition; MET, mesenchymal-to-epithelial transition; miR, microRNA; TGF-β, transforming growth factor beta; TNF-α, tissue necrosis factor alpha; ZEB, zinc-finger enhancer binding.