|
Elongin
C
|
Interacts
with SOCS box [10]
|
|
Elongin
B
|
Interacts
with SOCS box [10]
|
|
Pericentrin
|
Cells
depleted of pericentrin enter senescence due to p53 activation [72].
|
|
SHC
(Src homology 2 domain containing) transforming protein 1 (SHC1)
|
Member
of the Shc protein family of molecular adaptors, SHC1 promotes apoptosis by
its redox activity. SHC1 is implicated in the control of oxidative stress and
life span in mammals [73].
|
|
Tripartite
motif-containing 28 (TRIM28 or KAP1)
|
TRIM28
is implicated in transcriptional control through its interaction with the
Kruppel-associated box repression domain. TRIM28 contributes to DNA repair
mechanisms [74].
|
|
5'-nucleotidase,
cytosolic II (NT5C2)
|
NT5C2
hydrolyzes 5-prime-monophosphate (IMP) and other purine nucleotides. NT5C2 is
implicated in the maintenance of a constant composition of intracellular
purine/pyrimidine nucleotides [75].
|
|
BCL2-associated
transcription factor 1 (BCLAF1)
|
BCLAF1,
a transcriptional repressor that interacts with members of the BCL2 family of
proteins, promotes apoptosis [76].
|
|
Human
positive cofactor 4 (PC4)
|
Suppressor
of oxidative mutator phenotype [77].
Accumulates at DNA damage foci [78].
|
