Table 2.
Effect of high fat diet ± AVE7688, Enalapril or Candoxatril on change in serum insulin, leptin, cholesterol, triglycerides, free fatty acids, adiponectin, 8-hydroxy deoxyguanosine, TBARS, and ACE activity.
| Determination | Control | High Fat | High Fat + AVE7688 | High Fat + Enalapril | High Fat + Candoxatril |
|---|---|---|---|---|---|
| (23) | (24) | (28) | (6) | (6) | |
| Insulin (ng/mL) | 1.28 ±.09 | 3.60 ± 0.43a | 1.78 ± 0.17b | 0.67 ± 0.05b | 3.74 ± 1.19a |
| Leptin (pM) | 446 ± 81 | 2052 ± 389a | 592 ± 75b | 1442 ± 430 | 2852 ± 260a |
| Cholesterol (mg/dL) | 303 ± 31 | 680 ± 29a | 347 ± 15b | 201 ± 22b | 255 ± 49 |
| Triglycerides (mg/dL) | 41.8 ± 4.1 | 71.5 ± 11.7 | 72.0 ± 9.1 | 67.3 ± 5.3 | 72.2 ± 8.9 |
| Free fatty acids (mmol/L) | 0.10 ± 0.01 | 0.20 ± 0.03a | 0.21 ± 0.02a | 0.28 ± 0.04a | 0.20 ± 0.04 |
| Adiponectin (μg/mL) | 7.9 ± 0.6 | 11.0 ± 0.7a | 9.5 ± 0.5 | 7.7 ± 0.7 | 7.8 ± 0.7 |
| 8-OH DG (ng/mL) | 1.88 ± 0.10 | 2.58 ± 0.17a | 1.91 ± 0.17b | 1.85 ± 0.09 | 1.88 ± 0.14 |
| TBARS (μg/mL) | 0.13 ± 0.01 | 0.50 ± 0.07a | 0.26 ± 0.05b | 0.71 ± 0.03a | 0.55 ± 0.02a |
| ACE activity (mU/mL/min) | 94 ± 8 | 75 ± 6 | 23 ± 2a,b | 4 ± 1a,b | 111 ± 14 |
Data are presented as the mean ± SEM. aP < .05 compared to control; bP < .05 compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.