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The role of the B-RAF/NF-κB/Snail/RKIP/PTEN circuitry in the regulation of EMT in melanoma. B-RAF induces EMT in melanoma through the constitutive activation of NF-κB and resulting in the up-regulation of the metastasis inducer, Snail. Inhibition of B-RAF by either up-regulation of RKIP or PTEN inhibits Snail expression. Expression of Snail down-regulates both RKIP and PTEN, thus providing a positive feedback loop for self-amplification and EMT.
