Figure 6. ICC stem cells are hyperplastic in Kit^K641E mice but unaffected by hypomorphic Kit (W/W^v) and Kitl (Sl/Sl^d) mutations or imatinib treatment.

(A) 14–16-day-old Kit^K641E mice. (B) Adult W/W^v mice. (C) Adult Sl/Sl^d mice. +/+: age- and strain-matched, wild-type controls. Box plots show median and interquartile range; n=3–4/group. The frequency of ICC and ICC progenitors was higher in juvenile wild-type littermates of the Kit^K641E mice than in the adult wild-type controls for the hypomorphic mutants. (D) Effects of 28-day in vivo imatinib treatment on ICC and precursors in adult Kit^K641E/+ mice lacking the neomycin resistance cassette (n=3/group).