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. 2001 Feb 13;98(4):1823–1828. doi: 10.1073/pnas.98.4.1823

Figure 4.

Figure 4

Effect of ADP receptor antagonists on DIP-thrombin-induced aggregation. (A) Pooled WP from GP V null mice were aggregated with DIP-thrombin (400 nM) in the presence (line 2) or absence (line 1) of 83 nM 2-methylthioadenosine monophosphate. (B) Pooled WP from GP V null mice were aggregated with DIP-thrombin (400 nM) in the presence (line 2) or absence (line 1) of 2 μM adenosine 3′,5′-bis-phosphate. (C) Human WP were preincubated with DMSO (line 1) or PAR 1 antagonist RWJ 56110 (40 μM; line 2) and pretreated with low doses of α-thrombin as described in Methods. Aggregation was initiated by the addition of DIP-thrombin (0.4 μM). (D) Human WP were preincubated with DMSO (line 1) or PAR 1 antagonist RWJ 56110 (40 μM; line 2). Aggregation was initiated by the addition of thrombin (1 nM).