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. 2001 Jan 30;98(4):1829–1834. doi: 10.1073/pnas.031582398

Figure 4.

Figure 4

Chronic effects of Cetrorelix in normal rats during or after the treatment for 10 days with a depot formulation of Cetrorelix pamoate, releasing 100 μg/day, on pituitary LH-RH-R mRNA expression and serum and pituitary LH. (a) LH-RH-R mRNA level after the treatment, % of control. (b) RT-PCR products of the pituitary LH-RH-R mRNA and β-actin mRNA, after separation by agarose gel electrophoresis and staining with ethidium bromide. Lane M, 100-bp DNA molecular weight marker; lanes 1, 2, and 3, Cetrorelix-treated; lanes 4, 5, and 6, untreated control. (c) Time course of serum LH measured on days 0, 1, 4, 7, and 10 of the Cetrorelix treatment. (d) Total pituitary LH after the treatment (% of untreated control). **, P < 0.01 vs. control.