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Motor activity is required for localization of Myo1b in filopodia. Localization of Myc-Myo1b R165A (A) and Myc-Myo1b G390A (D) in HeLa cells is shown. HeLa cells were stained with anti-PIP2 antibody (B and E; red) in addition to anti-Myc antibody (A and D; green). C and F are merged images of A and B and of D and E, respectively. Both motor-dead Myo1b constructs were enriched at the cell periphery but were not present in filopodia. Scale bars = 10 μm.
