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. 2010 Jun 30;285(36):27767–27775. doi: 10.1074/jbc.M110.115410

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Disruption of L3mbtl1 does not affect lifespan with or without sublethal dose irradiation. a, Kaplan-Meyer survival curves of L3mbtl1^−/− (n = 10) and littermate L3mbtl1^+/+ control mice (n = 10) reveal no significant difference in lifespan. b, single dose (6 grays (Gy)), non-lethal total body irradiation of cohorts of L3mbtl1^−/− (n = 10) and littermate L3mbtl1^+/+ control mice (n = 9) at 3 months of age results in no significant difference in survival; p values were calculated by log rank test. c, no alteration of global c-myc expression levels in L3mbtl1^−/− brains or ES cells as analyzed by Northern blot.