FIGURE 3.
Function of the transgenic mouse hearts overexpressing exon 7-deleted cTnT. Contractile and relaxation velocities, LVP development, and stroke volume were measured in ex vivo working heart preparations under different afterloads with preload fixed at 10 mm Hg (A) or under different preloads with afterload fixed at 55 mm Hg (B). The results demonstrated that all of the parameters indicated significantly decreased function of the exon 7-deleted (ΔE7) cTnT transgenic mouse hearts as compared with wild type controls. *, p < 0.05 compared with wild type using two-tailed Student's t test. Error bars indicate S.D.