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The distal control region is evolutionarily conserved. A, schematic representation of the region upstream of StAR from human, rat, mouse, and cow. Putative SF-1 binding sites are shown. Asterisks indicate position of the functional SF-1 binding sites for transcriptional activation. Evolutionarily conserved regions are boxed. B, comparison of sequences of the distal control region from human, rat, and mouse. The functional SF-1 binding sites for transcriptional activation are boxed.
