Table 1.

Pluripotency network proteins

Uniprot	Gene	Protein	Role [citation]	2-D-LC	1-DE	UF
P07356	Anxa2	Annexin A2	PluriNet [14]	X		X
P28352	Apex1	DNA-(apurinic or apyrimidinic site) lyase	PluriNet [14]	X	X	X
P24860	Ccnb1	G2/mitotic-specific cyclin-B1	PluriNet [14]			X
P00375	Dhfr	Dihydrofolate reductase	PluriNet [14]		X
P00493	Hprt1	Hypoxanthine-guanine phosphoribosyl-    transferase	PluriNet [14]	X	X	X
Q64433	Hspe1	10 kDa heat shock protein, mitochondrial	PluriNet [14]	X	X	X
Q922D8	Mthfd1	C-1-tetrahydrofolate synthase, cytoplasmic	PluriNet [14]		X	X
P50580	Pa2g4	Proliferation-associated protein 2G4	PluriNet [14]	X	X	X
Q3TF18	Parp1	Putative uncharacterized protein	PluriNet [14]	X	X	X
P62962	Pfn1	Profilin-1	PluriNet [14]	X	X	X
Q3TUQ5	Pnn	Pinin	PluriNet [14]		X
Q9CR16	Ppid	40 kDa peptidyl-prolyl cis-trans isomerase	PluriNet [14]	X	X	X
Q8CIG8	Prmt5	Protein arginine N-methyltransferase 5	PluriNet [14]		X	X
Q8R323	Rfc3	Replication factor C subunit 3	PluriNet [14]			X
Q8C671	Sfrs2	Putative uncharacterized protein	PluriNet [14]		X	X
Q62189	Snrpa	U1 small nuclear ribonucleoprotein A	PluriNet [14]	X	X	X
P54227	Stmn1	Stathmin	Interacts with     Zfp281 [12]	X	X	X
P70460	Vasp	Vasodilator-stimulated phosphoprotein	PluriNet [14]			X
P27641	Xrcc5	ATP-dependent DNA helicase 2 subunit 2	PluriNet [14]		X
Q99LI5	Zfp281	Zinc finger protein 281	Interacts with Nanog,     pluripotency     transcriptional network,     protein interaction     network [10, 11]	X

Proteins identified in the current study, but not in previous proteomic studies of R1 cells, which have been experimentally linked to the pluripotency network in human and/or mouse ES cells, are markers of pluripotency, or are part of the protein–protein network shared by pluripotent cells. Listed are the Uniprot accession number, gene, protein name, role and corresponding citation, and by which method it was identified in the current study.